How To Fast Safely—Without Losing Muscle Or Missing The Benefits (Part 2 of 2)

Dr. Josie Tenore, MD, MSc
Dr. Josie Tenore, MD, MSc
6 min read

How You Fast Matters

In Part 1, I shared what happens inside your body each day of a 5-day fast—from sugar depletion to stem cell renewal. But how you fast matters.

Let’s talk about how to fast safely, why water and juice fasts fall short, and what you can consume to get results without harming your health.

Why 5 Days?

The most powerful benefits—like autophagy, ketones, and stem cell activation—don’t kick in until Days 3–5. Shorter fasts help blood sugar or metabolism, but not full regeneration.

Why Water-Only or Juice Fasts Miss the Mark

Water-only fasting can cause muscle loss, fatigue, and nutrient depletion. Juice fasts overload the body with sugar, keeping you out of fat-burning and repair mode.

Supported Fasting: Best of Both Worlds

Give your cells what they need without disrupting the fasting signal. This protects your muscle, reduces risk, and keeps your brain online.

ProLon: The Most Studied Fasting-Mimicking Diet

Created by Dr. Valter Longo at USC’s Leonard Davis School of Gerontology, ProLon is a 5-day, plant-based meal plan designed to mimic fasting while feeding you just enough. Research shows it can lower biological age, reduce fat, and support cellular renewal. It’s simple, shelf-stable, and designed for busy people.

DIY Fasting-Mimicking Diet

Yes—you can DIY. But it must be done precisely:

  • Day 1: approximately 1,100 calories
  • Days 2–5: approximately 750–800 calories
  • Focus on high fat (avocado, olive oil), very low carbs and protein
  • Soups, olives, herbal teas, steamed veggies
  • Support with electrolytes, omega-3s, and mitochondrial nutrients (like ALA or NAC)

The goal: trick your body into healing mode without triggering digestion.

Nut-Free Options

If you’re allergic to nuts (common in many FMDs), swap for seed-based snacks (pumpkin, sunflower), roasted chickpeas, or coconut chips. Use a nutritionist to help replicate the macro balance.

Fasting Isn’t for Everyone

Avoid fasting—or get guidance—if you’re pregnant, breastfeeding, underweight, on certain medications, or managing chronic illness. This is metabolic therapy, not a trend.

A safe, structured 5-day fast can reset insulin, clean out damaged cells, reboot immunity, and support longevity. That’s the heart of healthgevity—feeling better, longer.

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Dr. Josie Tenore is a board-certified family physician and founder of TREVI Longevity & Aesthetics Institute in Highland Park, IL. She specializes in medically supervised weight loss, hormone therapy, and aesthetic treatments.

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