Mitochondrial Health: Why You’re Tired All The Time (And It’s Not Just Stress)

Dr. Josie Tenore, MD, MSc
Dr. Josie Tenore, MD, MSc
6 min read

Your Body’s Engines—And How To Make Them Run Better

Every cell in your body runs on energy. That energy comes from tiny engines called mitochondria.

You can’t see them, but you feel them every single day. When your mitochondria are working well, you feel clear-headed, energized, focused, and able to bounce back from workouts, illness, or stress. But when they’re struggling? You feel brain fog, fatigue, slower recovery, and unexplained weight gain or muscle loss.

So no—you’re not just tired because you’re busy. It might be your cellular batteries running low.

What Does Mitochondrial Health Mean?

Mitochondria are like tiny engines or power plants inside your cells. They take food and oxygen and turn it into fuel. But just like engines, they can:

  • Get clogged (with toxins, processed foods, stress)
  • Overheat (inflammation)
  • Burn out (aging, poor sleep, alcohol, medications)

Good mitochondrial health means efficient energy production, low oxidative stress, and resilience—your body handles stress better.

How to Support Your Mitochondria

You don’t have to jump straight to peptides or prescriptions. Start here:

1. Prioritize Protein and Movement

Muscle is mitochondrial gold. Strength training and walking both boost mitochondrial function.

2. Practice Mitochondrial Maintenance

  • Cold exposure (showers, ice packs)
  • Intermittent fasting
  • Deep, restful sleep
  • Red light therapy
  • Breathwork and oxygenation

3. Fuel the Engines Right

Mito-loving nutrients include B vitamins, magnesium, CoQ10, and alpha-lipoic acid. Avoid seed oils, excess sugar, and alcohol. Eat colorful veggies, healthy fats, and clean proteins.

What About Peptides?

Short answer: Not always necessary. Some peptides (like MOTS-c or 5-Amino-1MQ) can stimulate mitochondrial renewal—but they’re tools, not foundations. If your lifestyle is draining your mitochondria, no injection can undo that.

Use peptides when you’ve optimized sleep, nutrition, and stress—but still hit a wall, or when you’re recovering from illness or pushing through aging-related slowdowns, and always with a provider who monitors your labs and response.

Longevity isn’t just about lifespan—it’s about energy span. If you want to feel alive, focused, and strong, protect your mitochondria. You don’t have to be perfect—just consistent.

Request an Appointment

Schedule a consultation with Dr. Josie to discuss how we can help you reach your health and wellness goals.

Request Consultation

Dr. Josie Tenore is a board-certified family physician and founder of TREVI Longevity & Aesthetics Institute in Highland Park, IL. She specializes in medically supervised weight loss, hormone therapy, and aesthetic treatments.

Request a Consultation

Discover a balanced approach to health, beauty, and longevity. Schedule a consultation with Dr. Josie and our team today.

Request Consultation